Alpha Cell Stimulus-Secretion Coupling and Intercellular Interactions in Health and Type 2 Diabetes

Sklopitev med stimulacijo in sekrecijo in medcelične interakcije celic alfa v zdravju in pri sladkorni bolezni tipa 2

Authors

  • Viljem Pohorec University of Maribor, Faculty of Medicine, Institute of Physiology , Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo Author
  • Nika Zadravec University of Maribor, Faculty of Medicine, Institute of Physiology , Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo Author
  • Marko Turk University of Maribor, Faculty of Medicine, Institute of Physiology , Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo Author
  • Jurij Dolenšek University of Maribor, Faculty of Medicine, Institute of Physiology; University of Maribor, Faculty of Natural Sciences and Mathematics , Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo; Univerza v Mariboru, Fakulteta za naravoslovje in matematiko Author
  • Andraž Stožer University of Maribor, Faculty of Medicine, Institute of Physiology , Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo Author

DOI:

https://doi.org/10.18690/actabiomed.246

Keywords:

Alpha cell, calcium imaging, epinephrine, physiology, type 2 diabetes mellitus

Abstract

Beta cell dysfunction has long been thought to be at the root of type 2 diabetes pathogenesis; however, a bi-hormonal model of the disease appears to be more realistic. Alpha cells play a significant role in glucose homeostasis due to their communication with other cells within the islets of Langerhans and tissues like the liver through glucagon action. Although a concise model of their physiology is still lacking, new approaches provide more insight into the pathways of glucagon secretion and processes regulating it, which gives insight into alpha cell function in health and disease, with potential implications for type 2 diabetes management.

Author Biographies

  • Viljem Pohorec, University of Maribor, Faculty of Medicine, Institute of Physiology, Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo

    Maribor, Slovenia.

  • Nika Zadravec, University of Maribor, Faculty of Medicine, Institute of Physiology, Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo

    Maribor, Slovenia.

  • Marko Turk, University of Maribor, Faculty of Medicine, Institute of Physiology, Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo

    Maribor, Slovenia.

  • Jurij Dolenšek, University of Maribor, Faculty of Medicine, Institute of Physiology; University of Maribor, Faculty of Natural Sciences and Mathematics, Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo; Univerza v Mariboru, Fakulteta za naravoslovje in matematiko

    Maribor, Slovenia.

  • Andraž Stožer, University of Maribor, Faculty of Medicine, Institute of Physiology, Univerza v Mariboru, Medicinska fakulteta, Inštitut za fiziologijo

    Maribor, Slovenia.

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Published

12.07.2023

Issue

Vol. 16 No. 1 (2023)

Section

Review

License

Copyright (c) 2023 Viljem Pohorec, Nika Zadravec, Marko Turk, Jurij Dolenšek, Andraž Stožer (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Pohorec, V., Zadravec, N., Turk, M., Dolenšek, J., & Stožer, A. (2023). Alpha Cell Stimulus-Secretion Coupling and Intercellular Interactions in Health and Type 2 Diabetes: Sklopitev med stimulacijo in sekrecijo in medcelične interakcije celic alfa v zdravju in pri sladkorni bolezni tipa 2. Acta Medico-Biotechnica, 16(1), 21-28. https://doi.org/10.18690/actabiomed.246

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