Ultrasonographic and classical risk factors of carotid atherosclerosis in patients with type–2 diabetes mellitus

Ultrazvočni in klasični dejavniki tveganja karotidne ateroskleroze pri bolnikih s sladkorno boleznijo tipa 2

Authors

  • Marija Šantl Letonja General Hospital Murska Sobota , Splošna bolnišnica Murska Sobota Author
  • Mitja Letonja General Hospital Ptuj; University of Maribor, Faculty of Medicine , Splošna bolnišnica dr. Jožeta Potrča Ptuj ; Univerza v Mariboru, Medicinska fakulteta Author
  • Jovana Nikolajević Starčević University of Ljubljana, Medical Faculty, Institute of Histology and Embriology , Univerza v Ljubljani, Medicinska fakulteta, Inštitut za histologijo in embriologijo Author
  • Danijel Petrovič University of Ljubljana, Medical Faculty, Institute of Histology and Embriology , Univerza v Ljubljani, Medicinska fakulteta, Inštitut za histologijo in embriologijo Author

DOI:

https://doi.org/10.18690/actabiomed.81

Keywords:

diabetes mellitus, carotid atherosclerosis, markers of atherosclerosis

Abstract

Purpose: We determined the prevalence of the clinical and biochemical risk factors as well as the extent of atherosclerosis in carotid arteries in patients with diabetes mellitus type 2 (DMT2).

Methods: A total of 289 subjects with DMT2 and 157 healthy subjects were enrolled in this prospective cross–sectional study. Levels of total cholesterol, high–density lipoprotein– cholesterol (HDL–C), low–density lipoprotein–cholesterol (LDL–C), triglycerides, fasting blood glucose, fibrinogen, and high–sensitivity C–reactive protein (hsCRP) were measured using standard biochemical methods. Carotid atherosclerosis was assessed by ultrasonography. Intima media thickness (IMT), plaque type and plaque score were also determined.

Results: In comparison with healthy controls, DMT2 patients: were older and had a larger waist circumference; higher body mass index; higher prevalence of hypertension; higher values of fibrinogen, D–dimer, glucose, hsCRP, troponin and triglycerides. Patients with DMT2 had lower levels of LDL–C and they were treated more often with statins (70% vs. 5%). In comparison with healthy subjects, patients with DMT2 had an increased intima media thickness (1.09±0.12 vs. 0.98±0.14; P=0.001), higher plaque score, and more advanced types of plaques.

Conclusion: In comparison with healthy subjects, patients with DMT2 had an increased carotid IMT and higher plaque burden.

Author Biographies

  • Marija Šantl Letonja, General Hospital Murska Sobota, Splošna bolnišnica Murska Sobota

    Rakičan, Slovenia.

  • Mitja Letonja, General Hospital Ptuj; University of Maribor, Faculty of Medicine, Splošna bolnišnica dr. Jožeta Potrča Ptuj ; Univerza v Mariboru, Medicinska fakulteta

    Maribor, Slovenia.

  • Jovana Nikolajević Starčević, University of Ljubljana, Medical Faculty, Institute of Histology and Embriology, Univerza v Ljubljani, Medicinska fakulteta, Inštitut za histologijo in embriologijo

    Ljubljana, Slovenia.

  • Danijel Petrovič, University of Ljubljana, Medical Faculty, Institute of Histology and Embriology, Univerza v Ljubljani, Medicinska fakulteta, Inštitut za histologijo in embriologijo

     Prof., M.D., Ljubljana, Slovenia. E–mail: daniel.petrovic@mf.uni–lj.si

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Published

27.11.2021

Issue

Vol. 6 No. 1 (2013)

Section

Articles

How to Cite

Šantl Letonja, M., Letonja, M. ., Nikolajević Starčević, J. ., & Petrovič, D. (2021). Ultrasonographic and classical risk factors of carotid atherosclerosis in patients with type–2 diabetes mellitus: Ultrazvočni in klasični dejavniki tveganja karotidne ateroskleroze pri bolnikih s sladkorno boleznijo tipa 2 . Acta Medico-Biotechnica, 6(1), 33-44. https://doi.org/10.18690/actabiomed.81

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